Precision Medicine. Applied.

Leveraging the power of pharmacogenomics (PGx) to provide innovative and cost-effective precision medicine

Find out how you can control costs while improving the health and satisfaction of your members.

Pharmacogenomics

Just as there are known drug-drug interactions, there are also known drug-gene interactions. Pharmacogenomics is the study of how a person’s genes affect their response to specific medications. It is a type of precision medicine.

Scientists have found that specific areas of our DNA can predict whether certain medications will be effective or if they are likely to cause adverse drug reactions.

Currently, the FDA includes pharmacogenomic warnings on the labels of more than 200 medications.* A one-time saliva test lets doctors know whether a patient has specific genetic variants. This knowledge can influence dosing and the choice of medication. It can also alert physicians to avoid specific drugs.

*Table of Pharmacogenomic Biomarkers in Drug Labeling. US Food & Drug Administration website. Updated Feb 8, 2018. Accessed April 6, 2018. Available at: https://www.fda.gov/Drugs/ScienceResearch/ucm572698.htm

Drug Facts

Did you know?

Applied Precision Medicine
For Healthy Outcomes.

Coriell Life Sciences offers a comprehensive turnkey solution that enables organizations to offer one-time pharmacogenomic screening to their members. We’ll take care of everything—from sending invitations to reporting results. You don’t have to do a thing.

Reduce Healthcare Costs

Reduce Healthcare Costs While Improving the Health and Satisfaction of Plan Members

Our proven methodology leverages the findings of the Coriell Institute and current FDA data to ensure your members are taking only those drugs that work for them. We’re confident you’ll realize an immediate decrease in your pharmaceutical spend. Our clients also realize subsequent reductions in adverse medication reactions, hospitalizations, emergency department visits, slip and falls, and hospital readmissions.

Our Personalized Medicine

A Turnkey Medication Management Serving a Range of Customers

  • Self-insured businesses
  • National, state and local government benefit providers
  • Healthcare payers
  • Capitated Providers
  • Accountable Care Organizations (ACOs)
  • Countries with single-payer health care
  • Single-payer systems
Pharmacogenics

How it Works

Step 01

Population Risk Assessment

The program begins with an analysis of your claims data, which we run through the Coriell Health Insight Portal (CHIP). Our algorithm can evaluate your population to determine potential risks, the number of people likely to benefit, and estimate your ROI.

For those organizations wishing to take a phased approach, we can begin with the subset of cohorts who would most benefit from PGx testing.

Step 02

Invitations Sent

CLS sends out invitations to your members, inviting them to participate in the new, voluntary benefit. This invitation is customizable and can accommodate your branding and language specific to your member population.

Step 03

Enrollment and Onboarding

The invitations provide your members with a phone number to an enrollment hotline as well as a link to an online enrollment site. Both sources also offer educational information and answers to FAQs.

As part of the enrollment process, we gather information on a member’s over-the-counter (OTC) medications, vitamins and supplements, and lifestyle, all of which aid in their medication analysis.

Step 04

DNA Collection Kits Sent

After enrolling, members receive a DNA collection kit with your branding. They simply spit into the tube provided and mail it to our lab in the postage-paid package.

Step 05

Laboratory Analysis

Our network of laboratories conduct the pharmacogenetics (PGx) analysis on the members’ DNA samples. This data is then sent to Coriell Life Sciences.

Step 06

Genetic Interpretation

The PGx data is run through the proprietary CLS algorithms. These algorithms arebased on extensive scientific research and clinical outcomes data from the Coriell Institute. The data driving these algorithms are regularly updated to reflect current research findings, new drug approvals, and current FDA advisories.

Step 07

Comprehensive Reporting

Based on the genetic interpretation, CLS generates a comprehensive report that takes into account a member’s:

  • Pharmacogenomics
  • Prescription and over-the-counter medications
  • Supplements
  • Health conditions
  • Age
  • Lifestyle (foods, drinks, smoking, etc)

The report includes:

  • Pharmacogenomic alerts
  • Potential drug-drug interactions
  • Information from FDA black box warnings

The detailed report is presented in both printed and interactive form.

Step 08

Expert Pharmacist Review and Recommendations

A pharmacy review team—yours or ours uses the real-time decision support tool to analyze appropriate substitute medications and pricing. Clear clinical recommendations are generated in the form of a Medication Action Plan (MAP).

Step 09

Physician Outreach

Pharmacists reach out to members’ designated physicians to provide clear, medically-relevant, and clinically-actionable recommendations. Physicians do not need to pore through the report; nor are they responsible for any interpretation.

Step 10

Prescription Modifications

Physicians, in concert with their patients, can elect to act on the MAP recommendations by “deprescribing” problematic medications, and switching to safer and more effective medications.

Step 11

Ongoing Savings Realization

Organizations and their members realize immediate savings through deprescribing of unnecessary and harmful medications.

Longer-term and ongoing savings are realized due to reductions in:

  • adverse drug events
  • slip and falls
  • hospitalizations
  • emergency room visits
  • hospital readmissions

Our real-time dashboard enables organizations to track metrics based on your specific goals and KPIs.

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Let's Get Started

Do you want to control your healthcare spend while improving the health and satisfaction of your members? Contact us to find out how much you could save.

Call (888) 415-7834 – or let us know below how we can reach you, and we’ll be in touch.






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