January 18, 2023

New Research Finds Precision Medicine Has Reached a Global Tipping Point for Adoption

Life science leaders say the time is finally right for healthcare systems, employers, and governments to establish genome-informed clinical decision-making as the new standard of care


PHILADELPHIA January 18, 2023 – The Human Genome Project, completed nearly 20 years ago, promised an era of personalized healthcare. Now, new research reveals that precision prescribing using genetic testing has finally reached a global tipping point for adoption.

Published by Cambridge University Press, the peer-reviewed research—authored by life science leaders at Coriell Life Sciences—examines the maturation of critical factors required for the use of clinical genetics at scale. These advancements pave the way in enabling genome-informed clinical decision-making to be established as the new standard of care.

Precision prescribing using genetic testing has reached a global tipping point for adoption thanks to advancements across the healthcare ecosystem

“The stage is set for leaders around the world to change healthcare as we know it,” says co-author Scott Megill, President and CEO of Coriell Life Sciences, an international leader in precision medicine. “Studies have shown that using genetic information to provide more targeted therapeutic care significantly improves patient outcomes and reduces the overall cost of healthcare. This is especially true for pharmacogenomics (PGx), which uses an individual’s DNA to determine if medications are likely to be unsafe or ineffective for them specifically. We’re now entering a new age where barriers have transformed into boons for PGx-enabled precision medicine.”

The research tracks and analyzes global readiness for the large-sale implementation of PGx-enabled precision medicine based on five key factors:

  • Clinical Utility: The ability for meaningful clinical interpretations, recommendations, and guidelines, based on existing research and clinical understanding, to positively impact health outcomes
  • Laboratory Technology: Genotyping and sequencing technologies, and the standardization, regulation, and efficient production of laboratory data and rapid delivery of results at scale
  • User Acceptance: The degree to which patients, healthcare providers, and payers understand, embrace, and engage with genomic testing and the resulting insights
  • Implementation Models: The methods, processes, and practices employed to utilize PGx within health delivery systems
  • Economic Value: The demonstrated real-world benefits of cost savings and patient health improvement directly attributable to the application of PGx-enabled precision medicine

The paper also explores other important factors fueling readiness for PGx, including:

  • How PCR testing infrastructure built to support the COVID-19 pandemic and the massive global investment in point-of-care testing can be re-tasked toward population-scale deployment of PGx-enabled precision medicine

The paper emphasizes that, “Genetically informed prescribing offers one of the few realistic mechanisms to effectively reduce overall healthcare system costs while also improving individual patient care and outcomes.” The authors conclude, “The time is now for healthcare systems, employers, and governments to partner and establish genome-informed clinical decision-making as the new standard of care.”

These findings are supported by the Personalized Medicine Coalition (PMC), a group representing 220 member organizations comprised of innovators, scientists, patients, providers, and payers. PMC promotes the understanding and adoption of personalized medicine concepts, services, and products to benefit patients and health systems.

“This research details significant industry progress toward the clinical utilization of pharmacogenomics and personalized medicine on a population scale. Thanks to these advancements, which represent the work of multiple stakeholders, a new standard of care is finally within reach,” says Daryl Pritchard, Ph.D., Senior Vice President, Science Policy, Personalized Medicine Coalition.

Jay G. Wohlgemuth, M.D., Board Chair of the Personalized Medicine Coalition and SVP R&D and Chief Medical Officer for Quest Diagnostics, adds, “Pharmacogenomics provides insights, based on a patient’s unique genetics, to help identify the best therapy in advance, reducing the risk of adverse side effects and wasted time and dollars on an ineffectual treatment. As additional research shows, when delivered as part of a consumer-centric medication management program that includes informatics and pharmacy services, pharmacogenomics is scalable to large populations and can deliver actionable insights for a majority of individuals. The field has matured to a stage where the many payers of healthcare services – including employers and health plans – can confidently embrace pharmacogenomics in their population health programs to optimize medical spend and outcomes.”

To learn more, read the full paper, “Maturing pharmacogenomics factors deliver improvements and cost efficiencies.”


# # #

Media Contact:

Pamela Caruolo



To learn more about the benefits of implementing PGx-enabled precision medicine for your populations, complete the form below.